Liu, Shao-Lun , Adams, Keith .
Subfunctionalization of duplicated genes during the evolution of the Arabidopsis lineage.
Plant genomes contain many genes duplicated by polyploidy, segmental duplication, tandem duplication, and retroposition of cDNA, which can facilitate physiological and morphological novelty. Over time, there are four possible evolutionary fates for duplicated genes including (i) loss of gene function by pseudogenization, (ii) partitioning of the ancestral function through subfunctionalization or the duplication-degeneration-complementation (DDC) model, (iii) the acquisition of new gene function by the process of neofunctionalization, and (iv) gene redundancy because of gene dosage effects or the increase of genetic robustness against harmful mutations. A few cases of subfunctionalization have been documented in plants but the genomic extent of the phenomenon is unknown. In this study we have used gene pairs duplicated by an ancient polyploidy (about 2500 pairs) and tandem duplicate pairs (about 550 pairs) in Arabidopsis thaliana as a study system to identify potential cases of subfunctionalization, evaluate their frequency, and test the hypothesis that young duplicated genes show more subfunctionalization than older duplicated genes. Many cases of potential subfunctionalization were identified by analysis of microarray data and RT-PCR experiments. There were considerably more from tandem duplicates than from genes duplicated by polyploidy, and more from younger duplicates than older duplicates. This suggests that younger duplicated genes show more potentially subfunctionalized expression patterns than older duplicated genes.
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1 - University of British Columbia, Botanical Garden, Centre for Plant Research, and Botany Department, 6270 University Blvd, Vancouver, BC, V6T1Z4, Canada
Presentation Type: Oral Paper:Papers for Sections
Location: 182/I K Barber
Date: Monday, July 28th, 2008
Time: 11:15 AM